Most everyone has The Places Where Stuff Gets Shoved Away. Pick the one of those spots which is most central to your day-to-day activities; I'm thinking "hall closet" or "that one dresser drawer" rather than "in the basement" or "in a box under the bed".
Set a timer and spend 30 minutes pulling stuff out of it.
When the timer goes off, or when it's empty, dust and/or vacuum it.
Set the timer for another hour and put stuff back, but do not put back anything that belongs in the trash/recycling, Charity bag, Yard Sale box or somewhere more appropriate in the house.
(Why the second timer? To remind you to stay focused, keep moving and not have this chore eat up more of your day than it needs to).
Discardia 