Okay, you don't have to get the whole house in order tonight – don't feel overwhelmed, just pick the one room that's closest to sanity and get it together.
If you're going to spend extra effort over the long term on one room, I do recommend your bedroom be high on the list. Seems like I just get better rest when I lay down in a clean, reasonably tidy place and wake up without a bunch of to-do's as the first thing I see.