I talk a lot about cleaning up clutter along the way of making my main point about freeing your life of stuff that you don't actually want in it. I find it relaxing now, after steadily whittling away at my Discardian efforts for a few years, to be able to have my house ready for company with less than an hour of tidying up.
It's important to note, though, that your comfort level may be more or less messy than mine. I'm more of a neatnik than the folks in Thursday's New York Times article "Saying Yes To Mess", but much less so than some folks I know with pristine homes and perfectly ordered closets.
What matters in all cases is that there aren't things you don't want, blocking your enjoyment of what you do.
Think of the cottage style garden with flowers spilling out in clumps; embrace your particular mess and ruthlessly prune away any junk that detracts from your happiness.